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KMID : 0604520220480030287
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Journal of the Society of Cosmetic Scientists of Korea
2022 Volume.48 No. 3 p.287 ~ p.293
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Anti-Graying Effect of Pueraria Lobata Root Extract on Stress-Induced Hair Graying
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Hong Min-Jung
Park Byung-Cheol
Hong Yong-Deog
Kim Su-Na
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Abstract
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Gray hair is a representative sign of aging. Intrinsic aging, stress, and the external environment cause hair graying.
Stress is known to be a major factor in the early onset of hair graying. We previously found that Pueraia lobata root extract (PLRE) can prevent hair graying by promoting melanin formation. However, it remains unknown whether PLRE can prevent hair graying induced by conditions of stress. In this study, we confirmed the effect of PLRE on stress-induced hair graying. A reporter cell line was newly constructed to confirm the expression of microphthalamia-associated transcription factor (MITF), the main transcription factor for melanin production. MITF expression and melanin pigmentation were reduced in human hair follicle tissue treated with the stress hormone cortisol or H2O2 to induce oxidative stress. PLRE treatment restored MITF expression and increased the amount of melanin pigment in the hair follicle. The expression of Tyrosinase related proteins-2 (TRP-2), a melanin synthesis enzyme in the hair follicle, also increased. In conclusion, PLRE can effectively prevent the inhibition of melanin synthesis by stress hormones and oxidative stress.
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KEYWORD
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Pueraria lobata root extract, gray hair, MITF, melanin production
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